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Silymarin Studies and Resources
Clinic: Clinical studies with silymarin: Fibrosis progression is the end point
With interest the report by Angulo et al.on 27 patients with primary biliary cirrhosis (PBC) who did not respond biochemically to ursodeoxycholic acid (UDCA). In a noncontrolled one-armed study the authors investigated the effect of adding oral silymarin for 1 year to the standard regimen with UDCA. Since silymarin did not alter alkaline phosphatase, bilirubin, aspartate transaminase, albumin, or the Mayo ...[read more]
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In vitro and in vivo effects of four hepatoprotective agents: silymarin (LegalonR),(+)-cyanidanol-3 (CatergenR), 6,6-methylene-bis (2,2,4-trimethyl-1, 2-dihydroquinoline) (MTDQ), and 4,5-amino- imidazole-carboxamide-phosphate (Aica-P) on the expression and activity of superoxide dismutase enzyme and on certain cellular immune reactions were studied in lymphocytes (and erythrocytes) from cirrhotic patients and from healthy control subjects. In vitro incubation with these drugs inhibited lectin-induced lymphocyte transformation and some of them decreased ...[read more]
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The comparative effects of colchicine (10 microg day-1, p.o.) and silymarin (50 mg kg-1, p.o.) each given for 5 days a week on the chronic carbon tetrachloride (CCl4) liver damage were studied. Treatment with CCl4 resulted in a marked reduction of Na+, K+, and Ca2+-ATPases ...[read more]
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More than 2.5 million people in Germany suffer from chronic liver disease, most of them of alcoholic origin. Silymarin, extracted from silver thistle (Silybum marianum), was proved to develop antitoxic and antifibrotic effects in experimental as well as in human toxic liver damage ...[read more]
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BACKGROUND/AIMS: Silymarin has protective effects in different experimental conditions, but its efficacy in human liver cirrhosis has not been completely established. Therefore, this study was carried out to determine the effect of silymarin in alcoholics with liver cirrhosis with respect to survival and clinical and laboratory changes.
METHODS: From February 1986 to June 1989, we enrolled 200 alcoholics with ...[read more]
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Purified flavonolignan extracts from the fruits of the milk thistle (Silybum marianum (L.) Gaertn., syn. Carduus marianus L.) mainly contain silymarin, an isomer mixture of silibinin, isosilibinin, silicristin and silidianin. Silymarin is used for oral treatment of toxic liver damage (induced by alcohol, drugs or environmental toxins) and for supportive therapy in chronic inflammatory liver diseases and in liver cirrhosis. Silymarin and its main isomer silibinin, respectively, have been shown to possess antioxidant properties thus preventing lipid ...[read more]
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Background/Aims: Several studies have demonstrated that diabetic patients with cirrhosis require insulin treatment because of insulin resistance. As chronic alcoholic liver damage is partly due to the lipoperoxidation of hepatic cell membranes, anti-oxidizing agents may be usefu ...[read more]
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Nonmelanoma skin cancer is the most common cancer among humans; solar UV is its major cause. Therefore, it is important to identify agents that can offer protection against this cancer...[read more]
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